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Applied and Biological Chemistry - Biology Oriented Synthesis Science

RMIT AUSTRALIA

Royal Melbourne Institute of Technology, Melbourne, Australia

Main Areas of Interest

The advent of modern medicine is a critical inflection point in the evolution of our species. Indeed, the dramatic relief of human suffering, from the alleviation of pain to cures for infectious disease, can be clearly traced to advances in this area. The simple fact that chemical synthesis is at the heart of these achievements is practically unknown. In fact, most of the society commonly equates chemistry with pollution and being part of a problem rather than celebrating the almost magical molecular milestone solutions it continually provides. My outlook is that research is really relevant when it has impact on human lives, and improving lives is the only goal that really matters.

Synthesis of Click-Triazole-Polyphenol Molecular Platforms for Antiamyloidogenic Drug Discovery : Driven by rapid global population ageing, more than 44 million people worldwide are living with dementia, and this number is predicted to nearly double every 20 years increasing to 115 million by 2050 as a result of an increasing human lifespan. With one case diagnosed every 4 seconds, and a global economic cost of US$604 billion—1% of global GDP—the challenge posed by the social and economic burden of dementia is unequivocal. The challenge ahead is very broad and a larger vision and set of actions are needed to improve the lives of people with dementia and their caregivers worldwide. Our dementia research project concerns the chemistry of inhibition of the biophysical toxic nature of the amyloid disease mechanisms.

Techniques You Will Learn

Experimental techniques you will learn hands-on during your program here:

Chemical synthesis

Experimental Risk assessment analysis

Dangerous goods analysis

Laboratory Safety Protocols

Manipulation of chemicals, glassware

Handling pyrophoric reagents

Organic compound purification, recrystallization,

Flash column chromatography, TLC

Instrumental analysis: Gas-chromatography [GC], GC-MS, 1H, 13C NMR

HPLC product analysis

NMR, MS interpretation

Microwave irradiation heating

Thioflavin T fluorescence assays

Biophysical techniques, X-ray crystal analysis

Curriculum

This project is significant because it will:

Provide the Trialect-trainee excellent opportunities in a diverse range of skills;

develop interdisciplinary molecular and biophysical strategies for scientists to tackle an urgent human health problem;

Provide insights into the mechanistic binding pathways operating between polyphenols and amyloid protein;

Enable the applications of newly discovered antiamyloidogenic scaffolds for the development of therapeutic agents against AD and dementia;

lead to publications in highly-ranked journals (12 week stay is required to publish a paper)

Accommodation

Try Airbnb

Fees and Program Logistics

This program has the following durations available:

Duration	Fee

Who Can Apply

Host Details

Host Name: Helmut Hugel

Affiliation: RMIT AUSTRALIA

Address: Royal Melbourne Institute of Technology, Melbourne, Australia

Website URL: https://www.rmit.edu.au

Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.

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